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Biotechnol., doi: 10.1038/nbt.3294 (2015)

A distinct transcriptional profile in response to endothelial monocyte activating polypeptide II is partially mediated by JAK-STAT3 in murine macrophages

These benefits include supporting healthy detoxification, promoting a healthy immune system, and moderating oxidative stress levels.* It is also essential for brain function, metabolic and biochemical reactions such as DNA synthesis and repair, and is critical in supporting the health of organs such as the lungs and kidneys.* Fun fact: in the body the liver cells can have as much as 10x the amount of active glutathione than other cells

Nonetheless, due to the high evolutionary conservation of the molecular clock, comparative analyses between the naked mole-rat and mice revealed that all major clock genes ( Bmal1, Clock, Per1/2, Cry1/2, Rev-Erb/ , and Ror-s ) are present in the naked mole-rats reference genome ( and are expressed in liver tissue, indicating that its circadian clock remains functional (Ghosh et al., 2021)